Evidence synthesis in pulmonary arterial hypertension: a systematic review and critical appraisal.

ABSTRACT:

Background

The clinical landscape of pulmonary arterial hypertension (PAH) has evolved in terms of disease definition and classification, trial designs, available therapies and treatment strategies as well as clinical guidelines. This study critically appraises published evidence synthesis studies, i.e. meta-analyses (MA) and network-meta-analyses (NMA), to better understand their quality, validity and discuss the impact of the findings from these studies on current decision-making in PAH.

Methods

A systematic literature review to identify MA/NMA studies considering approved and available therapies for treatment of PAH was conducted. Embase, Medline and the Cochrane's Database of Systematic Reviews were searched from database inception to April 22, 2020, supplemented by sear

SUBMITTER: Schlueter M 

PROVIDER: S-EPMC7388228 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature