Arsenite Binds to ZNF598 to Perturb Ribosome-Associated Protein Quality Control.

ABSTRACT: Arsenic pollution in drinking water is a widespread public health problem, and it affects approximately 200 million people in over 70 countries. Many human diseases, including neurodegenerative disorders, are engendered by the malfunction of proteins involved in important biological processes and are elicited by protein misfolding and/or loss of protein quality control during translation. Arsenic exposure results in proteotoxic stress, though the detailed molecular mechanisms remain poorly understood. Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite results in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10 and lysine 8 in RPS20, which are regulatory post-translational modifica

SUBMITTER: Tam LM 

PROVIDER: S-EPMC7388358 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature