Dysregulation of glycerophospholipid metabolism during Behcet's disease contributes to a pro-inflammatory phenotype of circulating monocytes.

ABSTRACT: Behçet's disease (BD) is a relapsing, multisystem and inflammatory condition characterized by systemic vasculitis of small and large vessels. Although the etiopathogenesis of BD remains unknown, immune-mediated mechanisms play a major role in the development of the disease. BD patients present leukocyte infiltration in the mucocutaneous lesions as well as neutrophil hyperactivation. In contrast to neutrophils, whose involvement in the pathogenesis of BD has been extensively studied, the biology of monocytes during BD is less well known. In this study, we analyzed the phenotype and function of circulating monocytes of 38 BD patients from Hospital of Braga. In addition, we evaluated the impact of inflammatory and metabolomic plasma environment on monocyte biology. We observed a worsening of

SUBMITTER: Mendes-Frias A 

PROVIDER: S-EPMC7388368 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature