Family history of autoimmune disease in relation to time-to-pregnancy, pregnancy loss, and live birth rate.

ABSTRACT: Several autoimmune conditions have adverse effects on reproductive outcomes, but the relationship between family history of autoimmune disease in women without these conditions and pregnancy is uncertain. The objective of this study was to determine if there is an association between a family history of an autoimmune condition and time-to-pregnancy (TTP), pregnancy loss, and live birth. This was a prospective cohort study from a RCT of 1228 adult women ages 18-40, who were healthy, had no history of infertility, were actively attempting to conceive, and had one or two prior pregnancy losses. Of these, 1172 women had data available regarding family history of autoimmune conditions. Women with an affected first-degree relative had similar TTP when compared to those without a FHx (fecundabili

SUBMITTER: Plowden TC 

PROVIDER: S-EPMC7388372 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature