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Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trial.


ABSTRACT:

SUBMITTER: Grau-Pujol B 

PROVIDER: S-EPMC7388426 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trial.

Grau-Pujol Berta B   Camprubí Daniel D   Marti-Soler Helena H   Fernández-Pardos Marc M   Guinovart Caterina C   Muñoz Jose J  

Trials 20200729 1


<h4>Objectives</h4>The aim of this study is to assess the efficacy of the use of pre-exposure prophylaxis (PrEP) with hydroxychloroquine against placebo in healthcare workers with high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in reducing their risk of coronavirus disease 2019 (COVID-19) disease during an epidemic period. As secondary objectives, we would like to: i) assess the efficacy of the use of PrEP with hydroxychloroquine against placebo in healthcare  ...[more]

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