Dataset Information

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.

ABSTRACT:

Introduction

Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.

Methods

Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis.

Results

During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer.

Conclusion

Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.

SUBMITTER: Trigo J

PROVIDER: S-EPMC7388434 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.

Trigo Javier J García-Azorín David D Planchuelo-Gómez Álvaro Á Martínez-Pías Enrique E Talavera Blanca B Hernández-Pérez Isabel I Valle-Peñacoba Gonzalo G Simón-Campo Paula P de Lera Mercedes M Chavarría-Miranda Alba A López-Sanz Cristina C Gutiérrez-Sánchez María M Martínez-Velasco Elena E Pedraza María M Sierra Álvaro Á Gómez-Vicente Beatriz B Arenillas Juan Francisco JF Guerrero Ángel L ÁL

The journal of headache and pain 20200729 1

<h4>Introduction</h4>Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.<h4>Methods</h4>Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demo ...[more]

PMID: 32727345

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Dataset Information

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.

Introduction

Methods

Results

Conclusion

Publications

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.

Similar Datasets

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