Trp53 regulates platelets in bone marrow via the PI3K pathway.

ABSTRACT: The p53 gene is well known as a key tumor suppressor gene; it is vital for hematopoietic stem cell differentiation and growth. In the present study, the change of platelets (PLTs) in p53 knockout mice (p53^-/- mice) was investigated. The peripheral blood cell subsets and PLT parameters in p53^-/-mice were compared with those in age-matched p53^+/+ mice. Bleeding time as well as the alteration of PLT levels, were analyzed with the PLT marker CD41 antibody using flow cytometry. The results revealed that the number of PLTs in p53^-/- mice was significantly lower than that in p53^+/+ mice. Bleeding time was prolonged in the peripheral blood of p53^-/- mice compared with that of p53^+/+ mice. Furthermore, the related gene exp

SUBMITTER: Yang M 

PROVIDER: S-EPMC7388439 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature