Retinoic acid induces differentiation in neuroblastoma via ROR1 by modulating retinoic acid response elements.

ABSTRACT: Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has been revealed to progress the cells from their stem‑cell state to a mature neuronal state gaining classical neuronal characteristics, including the suppression of proliferation. However, the molecular mechanism underlying the action of RA treatment remains to be elucidated. In the present study, a novel mechanism of RA‑induced differentiation via regulation of receptor tyrosine kinase‑like orphan receptor 1 (ROR1) is reported. ROR1 is overexpressed in neuroblastoma but signif

SUBMITTER: Illendula A 

PROVIDER: S-EPMC7388440 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature