Identification of a prognosis‑associated signature associated with energy metabolism in triple‑negative breast cancer.

ABSTRACT: At present, a large number of exciting results have been found regarding energy metabolism within the triple‑negative breast cancer (TNBC) field. Apart from aerobic glycolysis, a number of other catabolic pathways have also been demonstrated to participate in energy generation. However, the prognostic value of energy metabolism for TNBC currently remains unclear. In the present study, the association between gene expression profiles of energy metabolism and outcomes in patients with TNBC was examined using datasets obtained from the Gene Expression Omnibus and The Cancer Genome Atlas. In total, four robust TNBC subtypes were identified on the basis of negative matrix factorization clustering and gene expression patterns, which exhibited distinct immunological, molecular and prognostic (dis

SUBMITTER: Li C 

PROVIDER: S-EPMC7388543 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature