Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation.

ABSTRACT: Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia, affects millions of people worldwide. AF is associated with common risk factors, including hypertension, diabetes mellitus, and obesity, and serious complications such as stroke and heart failure. Notably, AF is progressive in nature, and because current treatment options are mainly symptomatic, they have only a moderate effect on prevention of arrhythmia progression. Hereto, there is an urgent unmet need to develop mechanistic treatments directed at root causes of AF. Recent research findings indicate a key role for inflammasomes and derailed proteostasis as root causes of AF. Here, we elaborate on the molecular mechanisms of these 2 emerging key pathways driving the pathogenesis of AF. First the rol

SUBMITTER: Li N 

PROVIDER: S-EPMC7388703 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature