Amygdala Circuitry During Neurofeedback Training and Symptoms' Change in Adolescents With Varying Depression.

ABSTRACT: Typical adolescents have increased limbic engagement unchecked by regulatory medial prefrontal cortex (PFC) activity as well as heightened self-focus. The resulting emotion dysregulation and self-focused rumination make adolescents more susceptible to depression and suicide attempts. Heightened self-focus converges with mental illness among depressed adolescents, who deploy exaggerated attention to negative self-relevant stimuli and neglect positive ones as part of depression's phenomenology. This results in rigid negative self-representations during an identity formative period with potential lifetime repercussions. Current empirically supported treatments fail to allay recurrent depression. Evidence-based interventions for illnesses linked to suicide ideation and attempts (e.g., depressi

SUBMITTER: Quevedo K 

PROVIDER: S-EPMC7388863 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature