[Antimicrobial susceptibility and antigen genotypes of Bordetella pertussis strains isolated from neonates].

ABSTRACT: OBJECTIVE:To investigate the alternative antimicrobial drugs for the treatment of neonatal pertussis and the antigen genotypes of Bordetella pertussis (B. pertussis) strains. METHODS:A total of 32 B. pertussis strains isolated from neonates between May 2013 and July 2018 were used in this study. E-test stripes were used to measure the minimal inhibitory concentration (MIC) of 18 antimicrobial drugs including erythromycin, sulfamethoxazole-trimethoprim (SMZ) and ampicillin. The 23S rRNA gene of isolated strains was amplified and sequenced to identify the mutation site of erythromycin resistance gene, and the seven antigen genotypes of B. pertussis strains (ptxA, ptxC, ptxP, prn, fim2, fim3 and tcfA2) were analyzed. RESULTS:Of the 32 B. pertussis strains, 25 (78%) were resistant to erythromy

SUBMITTER: Li LJ 

PROVIDER: S-EPMC7389359 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature