Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma.

ABSTRACT:

Background

The immune response within the tumor microenvironment plays a key role in tumorigenesis and determines the clinical outcomes of head and neck squamous cell carcinoma (HNSCC). However, to date, a paucity of robust, reliable immune-related biomarkers has been identified that are capable of estimating prognosis in HNSCC patients.

Methods

High-throughput RNA sequencing was performed in tumors and matched adjacent tissues from five HNSCC patients, and the immune signatures expression of 730 immune-related transcripts selected from the nCounter PanCancer Immune Profiling Panel were assessed. Survival analyzes were performed in a training cohort, consisting of 416 HNSCC cases, retrieved from The Cancer Genome Atlas (TCGA) database. A prognostic signature was built, using

SUBMITTER: Yao Y 

PROVIDER: S-EPMC7390201 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature