Plasma microRNAs biomarkers in mild cognitive impairment among patients with type 2 diabetes mellitus.

ABSTRACT:

Objectives

To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them.

Methods

This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed.

Results

MCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy ind

SUBMITTER: Salama II 

PROVIDER: S-EPMC7390351 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature