Elevated metabolites of acetaminophen in cord blood of children with obesity.

ABSTRACT: High-throughput metabolomics has been used cross-sectionally to evaluate differential metabolic profiles associated with human obesity. This study longitudinally assessed the cord blood metabolome to explore if metabolic signatures of obesity at age 3-5 are apparent at birth. In a nested case-control design, metabolomics analysis was performed on umbilical cord blood of 25 children who developed obesity by age 3-5 years, compared with 25 sex-matched non-obese children enrolled as part of an ongoing birth cohort. Logistic regression models were used to identify significant metabolites, adjusting for maternal pre-pregnancy obesity. Children who had obesity by age 3-5 years had elevated levels of medium and long chain fatty acids including stearate, oleate and palmitate at birth. Children wit

SUBMITTER: Sorrow P 

PROVIDER: S-EPMC7390435 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature