Necrotizing Fasciitis Within 72 hours After Presentation with Skin and Skin Structure Infection.

ABSTRACT:

Introduction

A small percentage of patients with skin infections later develop necrotizing fasciitis (NF). Diagnostic testing is needed to identify patients with skin infections at low risk of NF who could be discharged from the emergency department (ED) after antibiotic initiation. Elevated lactate has been associated with NF; existing estimates of the frequency of NF are based on retrospective reviews, and cases often lack testing for lactate. We present the incidence of patients with skin infections who developed NF and their baseline lactates.

Methods

In four phase-3 trials, 2883 adults with complicated or acute bacterial skin and skin structure infections were randomized to dalbavancin or comparator, with early and late follow-up visits through Day 28. We prospectively

SUBMITTER: Rappo U 

PROVIDER: S-EPMC7390563 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature