Unsupervised learning of early post-arrest brain injury phenotypes.

ABSTRACT:

Introduction

Trials may be neutral when they do not appropriately target the experimental intervention. We speculated multimodality assessment of early hypoxic-ischemic brain injury would identify phenotypes likely to benefit from therapeutic interventions.

Methods

We performed a retrospective study including comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA) by one of 126 emergency medical services or in-hospital arrest at one of 26 hospitals from 2011 to 2019. All patients were ultimately transported to a single tertiary center for care including standardized initial neurological examination, brain imaging and electroencephalography; targeted temperature management (TTM); hemodynamic optimization targeting mean arterial pressure (MAP) >80 mmHg; and,

SUBMITTER: Elmer J 

PROVIDER: S-EPMC7390683 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature