The clinical effectiveness of intensive management in moderate established rheumatoid arthritis: The titrate trial.

ABSTRACT:

Objectives

Many trials have shown that intensive management is effective in patients with early active rheumatoid arthritis (RA). But its benefits are unproven for the large number of RA patients seen in routine care who have established, moderately active RA and are already taking conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs). The TITRATE trial studied whether these patients also benefit from intensive management and, in particular, achieve more remissions.

Methods

A 12-month multicentre individually randomised trial compared standard care with monthly intensive management appointments which was delivered by specially trained healthcare professionals and incorporated monthly clinical assessments, medication titration and psychosocial support. The

SUBMITTER: Scott D 

PROVIDER: S-EPMC7390769 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature