Network Approaches for Dissecting the Immune System.

ABSTRACT: The immune system is a complex biological network composed of hierarchically organized genes, proteins, and cellular components that combat external pathogens and monitor the onset of internal disease. To meet and ultimately defeat these challenges, the immune system orchestrates an exquisitely complex interplay of numerous cells, often with highly specialized functions, in a tissue-specific manner. One of the major methodologies of systems immunology is to measure quantitatively the components and interaction levels in the immunologic networks to construct a computational network and predict the response of the components to perturbations. The recent advances in high-throughput sequencing techniques have provided us with a powerful approach to dissecting the complexity of the immune syste

SUBMITTER: Hao Shi 

PROVIDER: S-EPMC7390880 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature