Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC7390940 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Chen Zongwei Z Zhu Shaoyuan S Kindig Kayla K Wang Shengxuan S Chou Shih-Wei SW Davis Robin Woods RW Dercoli Michael R MR Weaver Hannah H Stepanyan Ruben R McDermott Brian M BM
Human molecular genetics 20200701 12
Perception of sound is initiated by mechanically gated ion channels at the tips of stereocilia. Mature mammalian auditory hair cells require transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations of the cognate genetic sequences result in dominant or recessive heritable deafness forms in humans and mice. In contrast, zebrafish lateral line hair cells, which detect water motion, require Tmc2a and Tmc2b. Here, we use standard and multiplex genome editing in conjunction with fun ...[more]