Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments.

ABSTRACT: The increasing interest toward biocompatible nanotechnologies in medicine, combined with electric fields stimulation, is leading to the development of electro-sensitive smart systems for drug delivery applications. To this regard, recently the use of pulsed electric fields to trigger release across phospholipid membranes of liposomes has been numerically studied, for a deeper understanding of the phenomena at the molecular scale. Aim of this work is to give an experimental validation of the feasibility to control the release from liposome vesicles, using nanosecond pulsed electric fields characterized by a 10 ns duration and intensity in the order of MV/m. The results are supported by multiphysics simulations which consider the coupling of three physics (electromagnetics, thermal and pore

SUBMITTER: Caramazza L 

PROVIDER: S-EPMC7390969 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature