Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1^high memory phenotype CD4 T cells.

ABSTRACT: The transcription factors Egr2 and 3 are essential for controlling inflammatory autoimmune responses of memory phenotype (MP) CD4 T cells. However, the mechanism is still unclear. We have now found that the Egr2⁺ subset (PD-1^high MP) of MP CD4 T cells expresses high levels of checkpoint molecules (PD-1 and Lag3) and also markers of effector T cells (CXCR3 and ICAM-1). Egr2/3 are not required for PD-1^high MP CD4 cell development but mediate a unique transcriptional programme that effectively controls their inflammatory responses, while promoting homeostatic proliferation and adaptive responses. Egr2 negative PD-1^high MP CD4 T cells are impaired in homeostatic proliferation and adaptive responses against viral infection but display inflammatory res

SUBMITTER: Symonds AL 

PROVIDER: S-EPMC7391068 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature