Treatment-associated hemolysis in Kawasaki disease: association with blood-group antibody titers in IVIG products.

ABSTRACT: Hemolytic anemia resulting from IV Immunoglobulin (IVIG) treatment can be a serious complication, especially for those with underlying conditions with a high level of inflammation and after administration of high IVIG dosages, such as Kawasaki disease (KD), a multisystem vasculitis affecting young children. This hemolysis is caused by antibodies against blood groups A and B, but the precise mechanism for hemolysis is not known. We performed a single center, partly retrospective, partly prospective study of a cohort of 581 patients who received IVIG for treatment of KD from 2006 to 2013. Factors associated with hemolysis were identified through univariable and multivariable logistic regression. Six IVIG preparations were assayed for their hemolytic effect with serological and cellular assay

SUBMITTER: Bruggeman CW 

PROVIDER: S-EPMC7391134 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature