Recipient and donor genetic variants associated with mortality after allogeneic hematopoietic cell transplantation.

ABSTRACT: Many studies have suggested that genetic variants in donors and recipients are associated with survival-related outcomes after allogeneic hematopoietic cell transplantation (HCT), but these results have not been confirmed. Therefore, the utility of testing genetic variants in donors and recipients for risk stratification or understanding mechanisms leading to mortality after HCT has not been established. We tested 122 recipient and donor candidate variants for association with nonrelapse mortality (NRM) and relapse mortality (RM) in a cohort of 2560 HCT recipients of European ancestry with related or unrelated donors. Associations discovered in this cohort were tested for replication in a separate cohort of 1710 HCT recipients. We found that the donor rs1051792 A allele in MICA was associa

SUBMITTER: Martin PJ 

PROVIDER: S-EPMC7391140 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature