Acute and chronic stress prevents responses to pain in zebrafish: evidence for stress-induced analgesia.

ABSTRACT: The state of an animal prior to the application of a noxious stimulus can have a profound effect on their nociceptive threshold and subsequent behaviour. In mammals, the presence of acute stress preceding a painful event can have an analgesic effect whereas the presence of chronic stress can result in hyperalgesia. While considerable research has been conducted on the ability of stress to modulate mammalian responses to pain, relatively little is known about fish. This is of particular concern given that zebrafish (Danio rerio) are an extensively used model organism subject to a wide array of invasive procedures where the level of stress prior to experimentation could pose a major confounding factor. This study, therefore, investigated the impact of both acute and chronic stress on the beh

SUBMITTER: Thomson JS 

PROVIDER: S-EPMC7391404 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature