Evolutionarily conserved transcription factors drive the oxidative stress response in Drosophila.

ABSTRACT: As organisms are constantly exposed to the damaging effects of oxidative stress through both environmental exposure and internal metabolic processes, they have evolved a variety of mechanisms to cope with this stress. One such mechanism is the highly conserved p38 MAPK (p38K) pathway, which is known to be post-translationally activated in response to oxidative stress, resulting in the activation of downstream antioxidant targets. However, little is known about the role of p38K transcriptional regulation in response to oxidative stress. Therefore, we analyzed the p38K gene family across the genus Drosophila to identify conserved regulatory elements. We found that oxidative stress exposure results in increased p38K protein levels in multiple Drosophila species and is associated

SUBMITTER: Ryan SM 

PROVIDER: S-EPMC7391405 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature