CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.

ABSTRACT:

Background

Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear. This study aims to verify the role and the underlying mechanisms of CD147 in collective invasion in hepatocellular carcinoma.

Methods

Immunostaining was used to analyze human hepatocellular carcinoma specimens and three-dimensional cultures. Three-dimensional invasion model was established to mimic in vivo invasion. RNA-sequencing was used to identify downstream effectors.

Results

Human hepatocellular carcinoma underwent collective invasion and CD147 was observed to be upregulated at the invasive front of tumor cell groups. CD147 was demonstrated to promote collective invasion using the modified three-dimensional in

SUBMITTER: Wang SJ 

PROVIDER: S-EPMC7391525 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature