Population variation in miRNAs and isomiRs and their impact on human immunity to infection.

ABSTRACT:

Background

MicroRNAs (miRNAs) are key regulators of the immune system, yet their variation and contribution to intra- and inter-population differences in immune responses is poorly characterized.

Results

We generate 977 miRNA-sequencing profiles from primary monocytes from individuals of African and European ancestry following activation of three TLR pathways (TLR4, TLR1/2, and TLR7/8) or infection with influenza A virus. We find that immune activation leads to important modifications in the miRNA and isomiR repertoire, particularly in response to viral challenges. These changes are much weaker than those observed for protein-coding genes, suggesting stronger selective constraints on the miRNA response to stimulation. This is supported by the limited genetic control of miRNA

SUBMITTER: Rotival M 

PROVIDER: S-EPMC7391576 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature