Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen.

ABSTRACT:

Background

Arsenic exposure has become a matter of worldwide concern, which is associated with immune-related diseases. However, little is known about its effect on inflammatory immune-related homeostasis. The purpose of our study was to understand the potential tuning of above responses exerted by chronic arsenic exposure.

Methods

Kunming mice were treated with 25 and 50 mg/L sodium arsenite for 1, 3 and 12 months via drinking water. At different endpoints of arsenic exposure, all animals and the whole spleen of the mice were weighed. The total arsenic levels of spleen were determined by the HPLC-HG-AFS method. Splenic NF-κB, MAPK and NRF2 protein levels by treatment of 25 mg/L NaAsO₂ for 1, 3 and 12 months and 25 mg/L and 50 mg/L NaAsO₂ for 12 months

SUBMITTER: Yan N 

PROVIDER: S-EPMC7391604 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature