Multiple formin proteins participate in glioblastoma migration.

ABSTRACT:

Background

The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators of this particularly invasive behavior. One approach is to look for actin regulating proteins that might be targeted by future anti-cancer therapy. The formin family of proteins orchestrates rearrangement of the actin cytoskeleton in multiple cellular processes. Recently, the formin proteins mDia1 and mDia2 were shown to be expressed in glioblastoma in vitro, and their function could be modified by small molecule agonists. This finding implies that the formins could be future therapeutic targets in glioblastoma.

Methods

In cell studies, we investigated the changes in expression of the 15 human formins in primary glioblasto

SUBMITTER: Heuser VD 

PROVIDER: S-EPMC7391617 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature