Early administration of glucocorticoid for thyroid storm: analysis of a national administrative database.

ABSTRACT:

Background

Thyroid storm is a life-threatening disease with a mortality rate of over 10%. Although glucocorticoids have been recommended as a treatment option for thyroid storm, supportive evidence based on a large-scale clinical research is lacking. The objective of the current study was to evaluate the beneficial effects of glucocorticoids in the treatment of patients with severe thyroid storm.

Methods

A retrospective nationwide cohort study was conducted using a Japanese national administrative claims database. Patients admitted to intensive care units due to severe thyroid storm between the financial years 2013 and 2017 were included in the study. The primary outcome was in-hospital mortality; secondary outcomes were mortality within 30 days and insulin administration du

SUBMITTER: Senda A 

PROVIDER: S-EPMC7391822 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature