Spatial heterogeneity of radiolabeled choline positron emission tomography in tumors of patients with non-small cell lung cancer: first-in-patient evaluation of [¹⁸F]fluoromethyl-(1,2-²H₄)-choline.

ABSTRACT: Purpose: The spatio-molecular distribution of choline and its metabolites in tumors is highly heterogeneous. Due to regulation of choline metabolism by hypoxic transcriptional signaling and other survival factors, we envisage that detection of such heterogeneity in patient tumors could provide the basis for advanced localized therapy. However, non-invasive methods to assess this phenomenon in patients are limited. We investigated such heterogeneity in Non-Small Cell Lung Cancer (NSCLC) with [¹⁸F]fluoromethyl-(1,2-²H₄) choline ([¹⁸F]D4-FCH) and positron emission tomography/computed tomography (PET/CT). Experimental design: [¹⁸F]D4-FCH (300.5±72.9MBq [147.60-363.6MBq]) was administered intravenously to 17 newly diagnosed NS

SUBMITTER: Dubash S 

PROVIDER: S-EPMC7392021 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature