Mendelian Randomization Study of Obesity and Cerebrovascular Disease.

ABSTRACT:

Objective

To systematically investigate causal relationships between obesity and cerebrovascular disease and the extent to which hypertension and hyperglycemia mediate the effect of obesity on cerebrovascular disease.

Methods

We used summary statistics from genome-wide association studies for body mass index (BMI), waist-to-hip ratio (WHR), and multiple cerebrovascular disease phenotypes. We explored causal associations with 2-sample Mendelian randomization (MR) accounting for genetic covariation between BMI and WHR, and we assessed what proportion of the association between obesity and cerebrovascular disease was mediated by systolic blood pressure (SBP) and blood glucose levels, respectively.

Results

Genetic predisposition to higher BMI did not increase the risk of

SUBMITTER: Marini S 

PROVIDER: S-EPMC7392199 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature