The DEAD-box RNA helicase CshA is required for fatty acid homeostasis in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is an opportunistic pathogen that can grow in a wide array of conditions: on abiotic surfaces, on the skin, in the nose, in planktonic or biofilm forms and can cause many type of infections. Consequently, S. aureus must be able to adapt rapidly to these changing growth conditions, an ability largely driven at the posttranscriptional level. RNA helicases of the DEAD-box family play an important part in this process. In particular, CshA, which is part of the degradosome, is required for the rapid turnover of certain mRNAs and its deletion results in cold-sensitivity. To understand the molecular basis of this phenotype, we conducted a large genetic screen isolating 82 independent suppressors of cold growth. Full genome sequencing revealed the fatty acid synthesis pathway

SUBMITTER: Khemici V 

PROVIDER: S-EPMC7392221 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature