A register-based approach to identifying treatment-resistant depression-Comparison with clinical definitions.

ABSTRACT:

Background

Several definitions of treatment-resistant depression (TRD) are used for clinical research, but no verified model for use in register data exists. We aimed to compare a novel model created for use in register data-the Karolinska Institutet Model (KIM)-to the clinical definitions regarding the proportion of patients identified with TRD, their characteristics and clinical outcomes.

Methods

All patients in Sweden initiating antidepressant treatment with a diagnosis of depression in specialized healthcare 2006-2014 were identified and followed in national registers. In KIM, patients who initiated a third sequential, >28-day antidepressant treatment trial were defined as having TRD. Proportion of TRD and patient characteristics were compared with register adaptations o

SUBMITTER: Hagg D 

PROVIDER: S-EPMC7392234 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature