Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal-directed action: A brief review.

ABSTRACT: Goal-directed action refers to selecting behaviors based on the expectation that they will be reinforced with desirable outcomes. It is typically conceptualized as opposing habit-based behaviors, which are instead supported by stimulus-response associations and insensitive to consequences. The prelimbic prefrontal cortex (PL) is positioned along the medial wall of the rodent prefrontal cortex. It is indispensable for action-outcome-driven (goal-directed) behavior, consolidating action-outcome relationships and linking contextual information with instrumental behavior. In this brief review, we will discuss the growing list of molecular factors involved in PL function. Ventral to the PL is the medial orbitofrontal cortex (mOFC). We will also summarize emerging evidence from rodents (compleme

SUBMITTER: Woon EP 

PROVIDER: S-EPMC7392403 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature