Characterization of two MHC II genes (DOB, DRB) in white-tailed deer (Odocoileus virginianus).

ABSTRACT:

Background

The major histocompatibility complex (MHC) is responsible for detecting and addressing foreign pathogens inside the body. While the general structure of MHC genes is relatively well conserved among mammalian species, it is notably different among ruminants due to a chromosomal inversion that splits MHC type II genes into two subregions (IIa, IIb). Recombination rates are reportedly high between these subregions, and a lack of linkage has been documented in domestic ruminants. However, no study has yet examined the degree of linkage between these subregions in a wild ruminant. The white-tailed deer (Odocoileus virginianus), a popular ruminant of the Cervidae family, is habitually plagued by pathogens in its natural environment (e.g. Haemonchus contortus, Elaeophora). Due

SUBMITTER: Ivy-Israel NMD 

PROVIDER: S-EPMC7392685 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature