Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.

ABSTRACT:

Background

We present a functional gene association network of the CLIP2 gene, generated by de-novo reconstruction from transcriptomic microarray data. CLIP2 was previously identified as a potential marker for radiation induced papillary thyroid carcinoma (PTC) of young patients in the aftermath of the Chernobyl reactor accident. Considering the rising thyroid cancer incidence rates in western societies, potentially related to medical radiation exposure, the functional characterization of CLIP2 is of relevance and contributes to the knowledge about radiation-induced thyroid malignancies.

Methods

We generated a transcriptomic mRNA expression data set from a CLIP2-perturbed thyroid cancer cell line (TPC-1) with induced CLIP2 mRNA overexpression and siRNA knockdown, respectivel

SUBMITTER: Selmansberger M 

PROVIDER: S-EPMC7392692 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature