Cortical reactivations of recent sensory experiences predict bidirectional network changes during learning.

ABSTRACT: Salient experiences are often relived in the mind. Human neuroimaging studies suggest that such experiences drive activity patterns in visual association cortex that are subsequently reactivated during quiet waking. Nevertheless, the circuit-level consequences of such reactivations remain unclear. Here, we imaged hundreds of neurons in visual association cortex across days as mice learned a visual discrimination task. Distinct patterns of neurons were activated by different visual cues. These same patterns were subsequently reactivated during quiet waking in darkness, with higher reactivation rates during early learning and for food-predicting versus neutral cues. Reactivations involving ensembles of neurons encoding both the food cue and the reward predicted strengthening of next-day func

SUBMITTER: Sugden AU 

PROVIDER: S-EPMC7392804 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature