Platelet concentrate and type II IL-1 receptor are risk factors for allergic transfusion reactions in children.

ABSTRACT:

Purpose

Allergic transfusion reactions (ATRs) are immunological reactions after transfusion. Interleukin-1 (IL-1) is a critical regulator for human diseases. We performed this study to investigate the association of type II IL-1 decoy receptor (IL1R2) expression with ATRs in children.

Methods

Children received blood transfusions between January and December 2019 were included. The age, sex, number and type of blood transfusion, allergic history, and medical history were collected and statistically analyzed. The blood samples were collected from children with and without ATRs for detecting the relative expression IL1R2 mRNA. Logistics regression analysis was performed to identify the risk factors for ATRs in children. The area under the receiver operating characteristic (ROC)

SUBMITTER: Hu W 

PROVIDER: S-EPMC7392823 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature