Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.

ABSTRACT:

Background

Endosomal trafficking and amyloidogenic cleavage of amyloid precursor protein (APP) is believed to play a role in the neurodegeneration observed in Alzheimer's disease (AD). Recent evidence has suggested that packaging and secretion of APP and its amyloidogenic cleaved products into small extracellular vesicles (EVs) may facilitate uptake of these neurotoxic factors during disease progression. However, the molecular mechanisms underlying trafficking of APP into EVs are poorly understood.

Results

In this study, the mechanism and impact of APP trafficking into extracellular vesicles (EVs) were assessed by a series of inducible gene knockdowns. We demonstrate that vesicle-associated proteins Alix and Syntenin-1 are essential for proper subcellular localization and ef

SUBMITTER: Cone AS 

PROVIDER: S-EPMC7392838 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature