Association between DNA methylation levels in brain tissue and late-life depression in community-based participants.

ABSTRACT:

Objective

Major depressive disorder (MDD) arises from a combination of genetic and environmental risk factors and DNA methylation is one of the molecular mechanisms through which these factors can manifest. However, little is known about the epigenetic signature of MDD in brain tissue. This study aimed to investigate associations between brain tissue-based DNA methylation and late-life MDD.

Methods

We performed a brain epigenome-wide association study (EWAS) of late-life MDD in 608 participants from the Religious Order Study and the Rush Memory and Aging Project (ROS/MAP) using DNA methylation profiles of the dorsal lateral prefrontal cortex generated using the Illumina HumanMethylation450 Beadchip array. We also conducted an EWAS of MDD in each sex separately.

Results

SUBMITTER: Huls A 

PROVIDER: S-EPMC7393126 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature