Effect of selective I_K,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation.

ABSTRACT:

Background and purpose

Inhibition of the G-protein gated ACh-activated inward rectifier potassium current, I_K,ACh may be an effective atrial selective treatment strategy for atrial fibrillation (AF). Therefore, the anti-arrhythmic and electrophysiological properties of a novel putatively potent and highly specific I_K,ACh inhibitor, XAF-1407 (3-methyl-1-[5-phenyl-4-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidin-6-yl]azetidin-3-ol), were characterised for the first time in vitro and investigated in horses with persistent AF.

Experimental approach

The pharmacological ion channel profile of XAF-1407 was investigated using cell lines expressing relevant ion channels. In addition, eleven horses were implanted with implantable cardiovert

SUBMITTER: Fenner MF 

PROVIDER: S-EPMC7393200 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature