A modular framework for the development of targeted Covid-19 blood transcript profiling panels.

ABSTRACT:

Background

Covid-19 morbidity and mortality are associated with a dysregulated immune response. Tools are needed to enhance existing immune profiling capabilities in affected patients. Here we aimed to develop an approach to support the design of targeted blood transcriptome panels for profiling the immune response to SARS-CoV-2 infection.

Methods

We designed a pool of candidates based on a pre-existing and well-characterized repertoire of blood transcriptional modules. Available Covid-19 blood transcriptome data was also used to guide this process. Further selection steps relied on expert curation. Additionally, we developed several custom web applications to support the evaluation of candidates.

Results

As a proof of principle, we designed three targeted blood trans

SUBMITTER: Rinchai D 

PROVIDER: S-EPMC7393249 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature