The effect of adjuvant radiotherapy on overall survival in adults with intracranial ependymoma.

ABSTRACT:

Background

Adult intracranial ependymoma is rare, and the role for adjuvant radiotherapy (RT) is not well defined.

Methods

We used the National Cancer Database (NCDB) to select adults (age ≥ 22 years) with grade 2 to 3 intracranial ependymoma status postresection between 2004 and 2015 and treated with adjuvant RT vs observation. Four cohorts were generated: (1) all patients, (2) grade 2 only, (3) grade 2 status post-subtotal resection only, (4) and grade 3 only. The association between adjuvant RT use and overall survival (OS) was assessed using multivariate Cox and propensity score matched analyses.

Results

A total of 1787 patients were included in cohort 1, of which 856 patients (48%) received adjuvant RT and 931 (52%) were observed. Approximately two-thirds of tumo

SUBMITTER: Prabhu RS 

PROVIDER: S-EPMC7393282 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature