Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors.

ABSTRACT:

Background

Cranial radiotherapy may damage the cerebral vasculature. The aim of this study was to understand the prevalence and risk factors of cerebrovascular disease (CVD) and white matter hyperintensities (WMHs) in childhood brain tumors (CBT) survivors treated with radiotherapy.

Methods

Seventy CBT survivors who received radiotherapy were enrolled in a cross-sectional study at a median 20 years after radiotherapy cessation. The prevalence of and risk factors for CVD were investigated using MRI, MRA, and laboratory testing. Tumors, their treatment, and stroke-related data were retrieved from patients' files.

Results

Forty-four individuals (63%) had CVD at a median age of 27 years (range, 16-43 years). The prevalence rates at 20 years for CVD, small-vessel disease,

SUBMITTER: Remes TM 

PROVIDER: S-EPMC7393284 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature