Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach.

ABSTRACT: The Corona virus Disease (COVID-19) is caused because of novel coronavirus (SARS-CoV-2) pathogen detected in China for the first time, and from there it spread across the globe creating a worldwide pandemic of severe respiratory complications. The virus requires structural and non-structural proteins for its multiplication that are produced from polyproteins obtained by translation of its genomic RNA. These polyproteins are converted into structural and non-structural proteins mainly by the main protease (Mpro). A systematic screening of a drug library (having drugs and diagnostic agents which are approved by FDA or other world authorities) and the Asinex BioDesign library was carried out using pharmacophore and sequential conformational precision level filters using the Schrodinger Suite.

SUBMITTER: Kanhed AM 

PROVIDER: S-EPMC7393348 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature