Ontology highlight
ABSTRACT:
SUBMITTER: Ozkan-Dagliyan I
PROVIDER: S-EPMC7393480 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cell reports 20200601 11
We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activity. The most potent combination, concurrent inhibition of RAF (RAFi) and ERK (ERKi), is highly synergistic at low doses in cell line, organoid, and rat models of PDAC, whereas each inhibitor alone is only cytostatic. Comprehensive mechanistic signaling studies ...[more]