TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection.

ABSTRACT:

Background

Head and neck squamous cell carcinoma is a heterogeneous disease with respect to the anatomic site of the primary tumor. On the other hand, it is highly recurrent, and once metastatic, it is associated with poor prognosis. TP53 is the most commonly mutated gene in primary disease. TP53 mutations occur in different structural elements of the protein while the biological outcome can be diverse.

Methods

Here we aimed to find differences in the mutation profile of TP53 in primary and metastatic disease and the impact of TP53 mutations in metastasis, specific copy number alterations, tumor mutation burden and response to immune checkpoint inhibitors. Somatic mutation and clinical data for 512 primary and 134 metastatic biopsies were studied.

Findings

Overall TP5

SUBMITTER: Klinakis A 

PROVIDER: S-EPMC7393519 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature