Epitranscriptomic 5-Methylcytosine Profile in PM_2.5-induced Mouse Pulmonary Fibrosis.

ABSTRACT: Exposure of airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM_2.5) is epidemiologically associated with lung dysfunction and respiratory symptoms, including pulmonary fibrosis. However, whether epigenetic mechanisms are involved in PM_2.5-induced pulmonary fibrosis is currently poorly understood. Herein, using a PM_2.5-induced pulmonary fibrosis mouse model, we found that PM_2.5 exposure leads to aberrant mRNA 5-methylcytosine (m⁵C) gain and loss in fibrotic lung tissues. Moreover, we showed the m⁵C-mediated regulatory map of gene functions in pulmonary fibrosis after PM_2.5 exposure. Several genes act as m⁵C gain-upregulated factors, probably critical for the development of

SUBMITTER: Han X 

PROVIDER: S-EPMC7393542 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature